Sean was born Kamaljeet Singh Jhooti in Hounslow, West London, England, to Sharan and Bindi Jhooti, Indian Punjabi Sikh immigrants. He was raised in Southall, and displayed musical talent at an early age. At age 11, he and his cousin Pritpal Rupra formed a hip hop duo named "Compulsive Disorder". His stage name at the time was MC "Nicky J", with the "J" being derived from the first letter of his last name "Jhooti". He eventually came to be known by the nickname "Jay" among his friends
He was a student at Latymer Upper School, the same private school that Hugh Grant, Heston Blumenthal and Lily Cole had attended. He finished his GCSEs as a "straight-A student" and then completed his A levels with an A grade in Biology and B grades in Mathematics and Chemistry.[28] He later enrolled in Barts and The London School of Medicine and Dentistry at Queen Mary, University of London, to study Medicine before he dropped out in 2003 to pursue a singing career. For his music career, he chose the stage name Jay Sean; "Jay" was the nickname his friends knew him as (derived from his previous stage name "Nicky J"), while "Sean" is derived from "Shaan"—a nickname he was called at home by his grandmother—which means "shining star" or "pride" in Punjabi.
After Sean's track "One Minute" fell into the hands of producer Rishi Rich, the Rishi Rich Project was formed (consisting of Rich, Sean and Juggy D) in 2003. Their first taste of UK chart success was the Asian underground song, "Dance with You (Nachna Tere Naal)", which became a Top 20 hit, peaking at #12. This led to Sean signing a £1m deal with Virgin Records, under their label Relentless Records. His second single, "Eyes on You," was his first solo effort and became a Top 10 hit, peaking at #6. His third single, "Stolen," peaked at #4, with Bollywood actress Bipasha Basu making an appearance in the video. His debut album, Me Against Myself, was released in 2004 and received much critical praise and acclaim. Sean was referred to as an "Asian sensation" and was praised for his experimental, creative fusion of contemporary R&B, British hip hop and Indian music.
Despite initially failing to reach the top 20 on the UK Albums Chart (where it peaked at #29), the album gradually managed to sell 100,000 copies in the UK and went on to become a substantial hit in India, selling over two million copies there. He made a brief appearance in the 2005 Bollywood film Kyaa Kool Hai Hum, providing the song "Dil Mera (My Heart)" to the soundtrack, based on "One Night" from his own debut album. Beyond India, the album sold over 300,000 copies across other parts of the world, including Europe, the Middle East, Southeast Asia, and Hong Kong. His performance of tracks from Me Against Myself on MTV Asia (alongside the Rishi Rich Project) had a television audience as large as 165 million viewers. It helped establish Sean as a major recognized artist across Asia and among the worldwide Desi diaspora, and remains his most successful album to date. With his debut album, Sean was influential in popularizing Indian-R&B fusion sounds in Asian underground and Indian pop music.
He recorded a 16 track album which was scrapped because Virgin felt the market had changed to where it was all about Pop music. In February 2006, after several delays of his second album, he left Virgin Records.
Jay Sean does various bits of work with the community. He has worked with BBC Blast doing Q&A's on tour events in an effort to "give something back". He has also supported the Aga Khan Foundation (AKF) in the charity event Partnership Walk and Run by performing in Regent's Park in 2004 and 2009.
In 2009, Sean performed in Justin Timberlake's charity concert to raise funds for the Shriners Hospital for Children, alongside artists such as MC Zani, Taylor Swift and Alicia Keys. It became one of the highest-earning charity events of the year, raising more than $9 million.