Curtis Jackson III grew up in the South Jamaica neighborhood of Queens, in New York City. He grew up without a father and was raised by his mother, Sabrina, who gave birth to him at the age of fifteen. Sabrina, a cocaine dealer, raised Jackson until the age of twelve, when she was murdered in 1988. After her death, Jackson moved into his grandparents' house with his eight aunts and uncles.
Jackson began boxing around the age of eleven. At the age of twelve, Jackson began dealing narcotics when his grandparents thought he was at after-school programs. He also took guns and drug money to school. In the tenth grade, he was caught by metal detectors at Andrew Jackson High School.
On June 29, 1994, Jackson was arrested for helping to sell four vials of cocaine to an undercover police officer. He was arrested again three weeks later when police searched his home and found heroin, ten ounces of crack cocaine, and a starter gun. He was sentenced to three to nine years in prison, but managed to serve six months in a shock incarceration boot camp where he earned his GED. He adopted the nickname "50 Cent" as a metaphor for "change". The name was derived from Kelvin Martin, a 1980s Brooklyn robber known as "50 Cent".
Jackson started rapping in a friend's basement where he used turntables to record over instrumentals. In 1996, a friend introduced him to Jam Master Jay of Run-DMC who was organizing his label Jam Master Jay Records. Jay taught him how to count bars, write choruses, structure songs, and how to make a record. Jackson's first official appearance was on a song titled "React" with the group Onyx on their 1998 album Shut 'Em Down. He credited Jam Master Jay as an influence who helped him improve his ability to write hooks. Jay produced Jackson's first album; however, it was never released. In 1999, after leaving Jam Master Jay, the platinum-selling producers Trackmasters took notice of Jackson and signed him to Columbia Records.
Jackson's popularity started to increase after the successful but controversial underground single, "How to Rob", which he wrote in half an hour while in a car on the way to a studio. The track comically explains how he would rob famous artists. The song was intended to be released with "Thug Love" featuring Destiny's Child, but two days before he was scheduled to film the "Thug Love" music video, Jackson was shot and confined to a hospital due to his injuries.
Jackson has established himself in a variety of fields. In November 2003, he signed a five year deal with Reebok to distribute a "G-Unit Sneakers" line as part of his G-Unit Clothing Company. He provided the voice-over as the protagonist in the video game, 50 Cent: Bulletproof, which was released for PlayStation 2, Xbox, and the PlayStation Portable. Its sequel, 50 Cent: Blood on the Sand, was released in early 2009. He worked with Glacéau to create a Vitamin Water drink called Formula 50. In 2007, Coca-Cola purchased Glacéau for US$4.1 billion. Forbes estimated Jackson, who owns a stake in the company, earned $100 million from the deal after taxes. He has teamed up with Right Guard to launched a body spray called Pure 50 RGX Body Spray and a condom line called Magic Stick Condoms, in which he planned to donate part of the proceeds to HIV awareness. Jackson has signed a multi-year deal with Steiner Sports to sell his memorabilia.
In 2005, Jackson made a cameo appearance on The Simpsons episode "Pranksta Rap", in which he makes light of his legal troubles. The same year, he starred alongside Terrence Howard in the semi-autobiographical film Get Rich or Die Tryin'. He starred in the 2006 film, Home of the Brave, as a soldier returning home from the Iraq War, traumatized after killing an Iraqi woman. Jackson is working on a role as a fighter in an Angola State Prison in Spectacular Regret alongside Nicolas Cage, and starred opposite Al Pacino and Robert De Niro in 2008's Righteous Kill, a movie regarding a police death. He also started the film production companies G-Unit Films in 2007 and Cheetah Vision in 2008. In August 2007, Jackson announced plans to launch a dietary supplement company in conjunction with his movie Spectacular Regret.
50 Cent with Val Kilmer at the AMAs 2009
The birth of his son changed Jackson's outlook on life: "when my son came into my life, my priorities changed, because I wanted to have the relationship with him, that I didn't have with my father". He credited his son for inspiring his career and being "motivation to go in a different direction".
Jackson has a tattoo of "Marquise" with an axe on his right biceps. Jackson dated actress Vivica A. Fox in 2003. After a few months, he announced their split up on the The Howard Stern Show when pictures from a photo shoot they did ended up on the cover of Today's Black Woman magazine without his knowledge.